Prevention of varicella to 12 months of age in individuals without a history of varicella or not vaccinated earlier.
Vaccination is anavar
especially shown to persons at high risk (see. Section “Special Instructions”) and persons staying in closed collectives (medical hospitals, dormitories, boarding schools, military units, etc.).
Emergency Prevention of varicella in previously bolevshih not vaccinated persons as well as persons from high-risk groups, in direct contact with sick chicken pox (family members, doctors, middle and junior medical staff, those involved in patient care).
1) anaphylactic reaction to this vaccine or any of its components in history.
2) Strong reaction or post-vaccination complications to the previous administration of the vaccine.
4) Primary immune deficiency at the level of white blood cells less than 1,200 cells / mm
5) Secondary immune deficiency at the level of white blood cells less than 1,200 cells / mm (for example, acute myelogenous leukemia, T-cell leukemia or malignant lymphoma – because of the risk of clinical symptoms and the apparent lack of growth in antibody titer due to the background disease or chemotherapy for these diseases).
6) Vaccination is temporarily contraindicated in the following categories patients:
- Individuals with elevated body temperature (37.5 ° C or higher, axillary) – to a temperature normalization and the clinical picture.
- Persons with acute illness – before the expiration of 2-4 weeks after recovery, and for non-severe acute respiratory viral infection, acute intestinal diseases etc. -. To a temperature normalization. In severe acute diseases of the nervous system (eg., Meningococcal meningitis) -up to the expiration of a longer period (up to 6 months from the onset of illness) after stabilization of residual changes.
- During exacerbation of chronic disease – before the onset of full or maximum achievable remission, including against the background of the maintenance treatment (except immunosuppressive).
- At the upcoming planned surgery – during the month before the operation date.
7) Implementation of immunosuppressive therapy (see. “Special Instructions” section).
Use with caution
when deciding on vaccination of persons following groups should take into account their overall health and physical examination data:
1) Patients with chronic diseases of the cardiovascular system, kidneys and liver.
2) Patients with hematological diseases.
3) Patients who for two days before a previous immunization were febrile or symptoms of an allergic reaction (eg, rash).
4) Patients with seizures in history.
5) Patients suffering from diseases associated with impaired immune function.
6) Patients in respect of which the presence is suspected allergy to any component of the vaccine.
Dosing and Administration
The drug is administered once subcutaneously in the deltoid muscles of the shoulder.
It is forbidden to enter the drug intravenously!
Immediately prior to inoculation of the vial stopper with the vaccine and treated with an alcohol by a puncture with a sterile syringe, introduce 0.7 ml of the supplied solvent (water for injection). Tak as a vaccine virus is photosensitive, dilution of the vaccine is carried out under conditions that exclude exposure to direct sunlight.
The time of complete dissolution of the lyophilizate – up to 2 minutes at a temperature of 20 ° C.
After reconstitution of the vial contents should be carefully inspected.
The reconstituted vaccine should be a clear, colorless or slightly whitish liquid without extraneous inclusions.
The vaccine should not be used in case of foreign inclusions, or other deviations from normal appearance.
Do not expose to direct light before and after dilution, since vaccine is sensitive to light and fast it is inactivated.
In 0.5 ml of reconstituted anavar vaccine contains 1 dose of the drug.
Before the introduction of the vaccine, make sure that the needle does not hit a blood vessel.
Storage of reconstituted vaccine is not to be.
When emergency prevention of varicella drug is used at the same dose, it must be administered within 72 hours after contact with the source of infection.
The injection site can occur rarely redness, swelling, and sealing, self-extending over several days. General reaction.
Sometimes (in 0.1% – 5%) in healthy children and adults after 1-3 weeks after vaccination marked fever and rash. These symptoms usually disappear on their own within a few days. In rare cases can develop symptoms of anaphylactoid reactions (eg, urticaria, dyspnea, lip edema, laryngeal edema).
In rare cases, immediately after vaccination and for 24 hours after the other may develop hypersensitivity reactions such as rash, itching, or fever.
In extremely rare cases (incidence 1: 1 LLC) in the period from a few days to three weeks after vaccination can develop idiopathic thrombocytopenic purpura.
When vaccination of persons at high risk in 14-30 days after vaccination may be observed papular and / or vesicular rash accompanied by fever. This reaction occurs in approximately 20% of vaccinees with acute lymphocytic leukemia. Vaccination of persons at high risk can then lead to the development of their herpes zoster, but the frequency of its occurrence is equal to or lower than the frequency of the disease in unvaccinated people who have had chicken pox.
1. As with other injections, vaccination procedure involves the need to have all the tools and medicines for relief of a possible anaphylactic reaction. Vaccinated must remain under the supervision of a healthcare worker for 30 minutes after vaccination.
Vaccinate to refrain from mental and physical stress on the day of vaccination and the next day, and not pollute the injection site. Parents are a child vaccinated should receive the same instructions.
2. In patients with acute lymphocytic leukemia vaccination following conditions must be met
1) the duration of remission for at least 3 months;
2) Number of lymphocytes not less than 500 / mm 3 ;
3) positive reaction in the test for delayed-type hypersensitivity using tuberculin dinitrohlorobenzola or phytohemagglutinin (PHA, 5 g / 0.1 mL),
4) Cancellation of chemotherapy (except 6-mercaptopurine) for at least 1 week prior to immunization and 1 week after immunization;
5) immunization time period does not coincide with the gain therapy for leukemia a therapy having an immunosuppressive action, such as radiation therapy.
Even when non-compliance with the above conditions (except pronounced reduction of the immune status, in particular in an amount of less than 500 lymphocytes / mm 3 ), the vaccine may be contact with a patient with chickenpox.
Clinical data show that in such circumstances the severity of natural infections is much higher than the possible side effects of the vaccine. In such cases, the vaccine should be administered up to 72 hours after exposure.
3. Vaccination of patients with solid tumors should be performed only if the tumor growth inhibition as a result of chemotherapy or surgery. The conditions described for patients with leukemia and also belong to this group of patients.
4. Vaccination of patients anavar receiving corticosteroids over nephrosis or severe bronchitis should be carried out under the condition stabilization clinical condition. In cases of suspected secondary immunodeficiency (see. ” Contraindications “) caused by drug therapy should be tested for delayed-type hypersensitivity to the vaccine (see section 2.3.) Of this section).
5. Since the elderly physiological functions of the body are reduced, it is necessary to carefully assess their health status prior to vaccination.
6. Women of childbearing age is recommended to avoid pregnancy for 1 month before vaccination and 2 months after vaccination.
Use during pregnancy and lactation
Vaccination is contraindicated during pregnancy.
The decision on vaccination during lactation should be made by the physician taking into account the ratio of the expected benefits and possible risks. According to clinical studies, vaccination in 12 seronegative breastfeeding mothers in breast milk were found traces of the virus contained in the vaccine; All children remained seronegative.
The interaction with other drugs
transfusion of blood components and maintenance of immunoglobulin
vaccine may be ineffective in patients receiving transfusions of blood components or immunoglobulin preparations as vaccine virus can be neutralized by antibodies to the virus Varicella Zoster. Vaccination of these patients should be postponed for a period of not less than 3 months from the date of receipt of the last of an immunoglobulin or blood components. In patients receiving high-dose therapy immunoglobulin (200 mg / kg or more), for example, when idnopaticheskoy thrombocytopenic purpura or Kawasaki disease, vaccination should be delayed for at least 6 months after the end of the immunoglobulin therapy.
If within 14 days after administration was introduced Okavaksa human immunoglobulin vaccination may not be effective. These patients should be vaccinated again not anavar earlier than 3 months after the preceding vaccination.
Other live vaccines
to persons who have received vaccinations with live vaccines (polio, measles, mumps, rubella, BCG, yellow fever vaccine), Okavaksom vaccination should be carried out not earlier than 4 weeks later.
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