Has anti-inflammatory, analgesic and antipyretic effect. By inhibiting cyclooxygenase type I and II, it inhibits the synthesis of prostaglandins. Antibradikininovoy possesses activity stabilizes lysosomal membranes and inhibits the release of these enzymes that contribute to tissue destruction in chronic inflammation. It anavar steroid steroid reduces the release of cytokines, inhibits neutrophil activity. Reduces morning stiffness and swelling of joints, increases range of motion. Ketoprofen lysine salt, as opposed to ketoprofen is rapidly dissolving molecule with neutral pH and almost no irritation to the gastrointestinal tract.
Absorption Ketoprofen lysine salt is rapidly absorbed: the time to reach maximum concentration (Tshah) after rectal administration of 45-60 minutes. The value of concentration in plasma is linearly dependent on the dose. Distribution. Up to 99% of the absorbed ketoprofen bound anavar for women to plasma proteins, primarily albumin. The volume of distribution – 0.1-0.2 l / kg. Easily it passes through the blood-tissue barriers and distributed in the tissues and organs.Ketoprofen penetrates well into the synovial fluid and connective tissue. While ketoprofen concentration in synovial fluid is somewhat lower than in the plasma, they are more stable (stored up to 30 hours). Metabolism. Ketoprofen is mainly metabolized by the liver, where it undergoes glucuronidation to form esters with glucuronic acid. Excretion. Metabolites derived mainly urine (up to 76% after 24 hours). The drug does not accumulates.
. Indications Symptomatic treatment of inflammatory processes accompanied by fever and pain, including inflammatory and rheumatic diseases of the joints:
- rheumatoid arthritis
- inflammation of periarticular tissues
Contraindications. Hypersensitivity (including to other. NSAIDs), “Aspirin” asthma, gastric ulcer and 12 duodenal ulcer (exacerbation), ulcerative colitis (exacerbation), Crohn’s disease, diverticulitis, peptic ulcer, hemophilia and others. coagulation disorders, chronic renal failure, children’s age (18 years), pregnancy (III trimester), lactation.
Be wary – anemia, asthma, alcoholism, smoking, alcoholic cirrhosis, hyperbilirubinemia, liver failure, diabetes, dehydration, sepsis, heart failure, edema, hypertension, blood disorders (including leucopenia), deficiency of glucose-6 -fosfatdegidrogenazy, disease, old age, pregnancy (I, II trimester). In the case of deterioration of the condition of the patient anavar only results should discontinue treatment with the drug.
Dosages and duration of method One suppository 2-3 times a day. The maximum daily dose of 480 mg. In elderly patients should not use more than 2 suppositories per day.
Side effects Gastrointestinal tract: abdominal pain, diarrhea, duodenitis, erosive and ulcerative lesions of the gastrointestinal tract, gastritis, gematomezis, esophagitis, stomatitis, melena. Liver: increase in bilirubin, increase in “liver” enzymes, hepatitis, hepatic failure, enlarged liver. Nervous system: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, malaise. Special senses: conjunctivitis, blurred vision. Skin: urticaria, angioedema, rash erythematous, itching, makulo- papular rash, increased sweating, erythema multiforme exudative (including Stevens anavar steroid steroid-Johnson syndrome). Urogenital: painful urination, cystitis, edema, hematuria, menstrual disorders. hemopoiesis organs: leykotsitopeniya, leukocytosis, lymphangitis, decrease of prothrombin time, purpura, thrombocytopenia, thrombocytopenic purpura, increased spleen size, vasculitis. Respiratory system: bronchospasm, dyspnea, sensation of spasm of the larynx, laryngeal spasm, laryngeal edema, rhinitis.Cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor. Allergic reactions: anaphylactoid reactions, swelling of the mouth, pharyngeal edema, periorbital edema. Local reactions: burning, itching, heaviness safest anabolic steroid in the anorectal area, worsening of hemorrhoids.
Overdose. Currently, the cases of drug overdose were reported.
The interaction Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumetsinol, rifampin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Reduces the uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, ethanol, side effects mineralkortikosteroidov, corticosteroids, estrogens . Reduces the effectiveness of antihypertensive and diuretics. The joint reception with others. , corticosteroids, ethanol, corticotropin may lead to ulceration and the development of gastro-intestinal bleeding, an increase in the risk of impairment of renal function. Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet , tsefaperazon, cefamandole and tsefotetanom increases the risk of bleeding. It increases the hypoglycemic effect of insulin and oral hypoglycemic agents (requires recalculation of the dose). Co-administration with sodium valproate causes a disturbance of platelet aggregation anavar pills. It increases concentration of plasma verapamil and nifedipine, lithium drugs methotrexate. Antacids and cholestyramine reduce the absorption. Use during pregnancy and breastfeeding. As with other shall not apply in the III trimester of pregnancy. Use of the drug in the I and II trimester should be closely monitored by the attending physician. Breast-feeding while using this drug should be discontinued.
Special instructions. During treatment necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys. If necessary, the definition of 17-keto steroids drug should be discontinued 48 hours prior to the study. Admission ketoprofen may mask signs of infection. If the kidney function and the liver is necessary to anavar steroid steroid decrease the dose and careful monitoring. The use of ketoprofen patients suffering from asthma can lead to asthma attacks. Women planning pregnancy, should refrain from taking the medication because may reduce the likelihood of implantation of the egg. Effects on ability to drive vehicles and management mechanisms. In the period of the drug should refrain from potentially dangerous activities associated with the need to concentration and rapid psychomotor reactions. achat steroide france cure anavar steroide anabolisant achat