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It has antianginal, hypotensive and antiarrhythmic effect. Non-selective beta-adrenoceptor blocking anadrol for sale, reduces the formation of catecholamines stimulated cAMP from ATP, resulting in reduced intracellular calcium intake has a negative chronotropic, dromo-, BATM and inotropic action (rate slows heart rate, inhibits conduction and excitability and reduces myocardial contractility).
The early use of beta-blockers total peripheral vascular resistance in the first 24 hours is increased (as a result of reciprocal increase in the activity of alpha-adrenoceptor stimulation and removal of beta2-adrenoceptor vessels skeletal muscle), but after 1-3 days back to the original, but with long-term appointment is reduced.
The hypotensive effect associated with a decrease in cardiac output, peripheral vascular sympathetic stimulation, decreased activity of the renin-angiotensin system (counts in patients with initial hypersecretion of renin), the sensitivity of the baroreceptors of the aortic arch ( occurs enhance their activity in response to lower BP) and the influence on the central nervous system. The hypotensive effect is stabilized by the end of 2 weeks of the course destination.
Antianginal effect is due to a decrease in myocardial oxygen demand (due to negative chronotropic and inotropic effect). The decrease in heart rate leads to a lengthening of diastole and improve myocardial perfusion. By increasing end-diastolic pressure in the left ventricle and increase the tension of the muscle fibers of the ventricles can increase oxygen demand, especially in patients with chronic heart failure.
The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP levels, hypertension ), a decrease in the rate of spontaneous excitation of the sinus and ectopic pacemakers and slowing of atrioventricular conduction. Inhibition of pulses observed mainly in the antegrade and to a lesser extent in the retrograde direction through the atrioventricular node, and on additional routes. According to the classification of antiarrhythmic drugs refers to the group preparations II. Reducing the severity of myocardial ischemia – by reducing myocardial oxygen demand, post-infarction mortality rate can also be reduced through anti-arrhythmic action.
The ability to prevent the development of headaches of vascular origin due to a decrease in the severity of the expansion of the cerebral arteries due to beta-adrenoblockade vascular receptor inhibition caused by catecholamines platelet aggregation and lipolysis, decrease platelet adhesiveness, preventing the activation of blood coagulation factors during the release of adrenaline stimulation of oxygen to the tissue and a decrease in renin secretion.
The decrease in tremor during treatment with propranolol may be due to blockade of beta2-adrenergic receptors. It increases blood atherogenic properties. Increases uterine contractions (spontaneous or caused by drugs that stimulate the myometrium). Increases the tone of the bronchi.

Quickly and adequately (90%) is absorbed by ingestion and relatively rapidly excreted from the body.The bioavailability after oral administration is 30-40% (the effect of “first pass” through the liver microsomal oxidation), with a long reception – increases (produced metabolites that inhibit the liver enzymes), its value depends on the nature of the food and the intensity of hepatic blood flow. It is metabolized in the liver by glyukuronirovaniya. Maximum plasma concentration is achieved within anadrol for sale  hours has a highly lipophilic, it accumulates in the lung tissue, brain, kidney, heart. It penetrates the blood-brain and placental barriers into breast milk. Contact with blood plasma proteins – 90-95%. The volume of distribution – 3 -5 l / kg. Stints with the bile into the intestine and is reabsorbed deglyukuroniziruetsya. The half – 3.5 hours, against the course of administration may be extended up to 12 hours. Excreted by the kidneys – 90%, in an unmodified form – less than 1%. Not removed by hemodialysis.

Indications for use:
Hypertension, angina, unstable angina, sinus tachycardia (including hyperthyroidism), supraventricular tachycardia, atrial tachyarrhythmia, supraventricular and ventricular premature beats, prevention of myocardial infarction (systolic blood pressure – more than 100 mmHg) essential tremor, migraine (prevention of attacks), as an aid in the treatment of thyrotoxicosis and thyrotoxic crisis (in case of intolerance thyreostatic drugs), the sympathetic-adrenal crises against the backdrop of diencephalic syndrome.

 Contraindications:

Hypersensitivity to the drug, atrioventricular block II and III degree, sinus block, sinus bradycardia, hypotension (systolic blood pressure below 90 mm Hg. Art.), Uncontrolled congestive heart failure IIB-IIIstepeni, acute heart failure, acute myocardial infarction (systolic blood pressure – less than 100 mm Hg), cardiogenic shock, pulmonary edema, sick sinus syndrome, Prinzmetal angina, cardiomegaly (with no signs of heart failure), vasomotor rhinitis, vascular occlusive disease periferichekih (complicated by gangrene, “intermittent claudication” or pain at rest), diabetes mellitus, metabolic acidosis (including diabetic ketoacidosis), bronchial asthma, a tendency to bronchospastic reactions, chronic obstructive pulmonary disease (including history), pheochromocytoma (without simultaneous use of alpha-blockers) , spastic colitis, concomitant use with antipsychotics and anxiolytics (chlorpromazine, trioxazine et al.), MAO inhibitors, lactation. Precautions – hepatic and / or renal failure, hyperthyroidism, myasthenia gravis, a heart failure, pheochromocytoma, psoriasis, pregnancy, allergic reaction in history, Raynaud’s syndrome, advanced age, the age of 18 years (effectiveness and safety have been established).

Dosage and administration:

Inside, before anadrol for sale meals, with liquid squeezed small amount of liquid.
When hypertension – inside, on 40 mg 2 times a day. With insufficient expression of the hypotensive effect dose increased to 40 mg three times or 80 mg 2 times a day. The maximum daily dose – 320 mg.
In angina, heart rhythm disturbances – at an initial dose of 20 mg 3 times a day, then increase the dose to 80-120 mg over 2-3 hours. The maximum daily dose – 240 mg.
For the prevention of migraine, as well as essential tremor -. A starting dose of 40 mg 3 times a day
. If abnormal liver and kidney function is necessary to decrease the dose of the drug
in renal impairment is necessary to reduce the initial dose or increase the interval between doses of the drug.
Prophylaxis of recurrent myocardial infarction – therapy is started between the 5th and the 21st day after myocardial infarction in a dose of 40 mg 3 times a day for 2-3 days. Then 80 mg 2 times a day. If necessary, can be administered 180-240 mg per day in divided doses.
In hyperthyroidism (aid) – 40 mg 3-4 times a day, if necessary possibly increasing doses up to 120-160 mg per day.

Side effect:

Cardio-vascular system: sinus bradycardia, atrioventricular block, heart failure, heart rate, conduction disturbances infarction, arrhythmias, lowering blood pressure, orthostatic hypotension, chest pain, spasm of peripheral arteries, cold extremities. On the part of the digestive tract: dry mouth , nausea, vomiting, diarrhea, constipation, epigastric pain, abnormal liver function, change in taste. From the nervous system: rarely – headache, insomnia, “nightmarish” dream, asthenic syndrome, decreased ability to rapid mental and motor reactions, agitation, depression, paresthesia, fatigue, weakness, dizziness, drowsiness, confusion, or momentary loss of memory, hallucinations, tremors. The respiratory system: rhinitis, nasal congestion, dyspnea, bronchospasm, laryngospasm. from the metabolic: hypoglycemia (in patients with diabetes mellitus type I), hyperglycemia (in patients with type II diabetes). from the senses: the dryness of the eyes (reduced secretion of tear fluid), the violation of visual acuity, keratoconjunctivitis. reproductive system: decreased libido, reduced potency. With the skin: alopecia, exacerbation of psoriasis flow, increased sweating, flushing of the skin, rash, psoriasiform skin reactions. From the endocrine: decreased thyroid function. Allergic reactions: skin rash, itching. Laboratory findings: agranulocytosis, increased activity of “liver” transaminase and bilirubin levels. The anadrol for sale impact on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia. Other: muscle weakness, back pain or joint pain, chest pain, leukopenia, thrombocytopenia and “cancellation” syndrome.

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