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Ovestin contains the natural female hormone estriol. In the period prior to menopause and postmenopausal anadrol 50mg (natural or surgical), estriol is used to treat symptoms caused by estrogen deficiency. Estriol has a selective effect mainly on the cervix, vagina, vulva and effekgiven especially for the treatment of urogenital symptoms caused by estrogen deficiency. In cases of atrophy of the vaginal mucosa estriol cause increased proliferation of the vaginal epithelium and cervix, stimulates its blood supply, contributes to the restoration of the epithelium, the normal microflora and the physiological pH of the vaginal environment has an impact on the quality and quantity of cervical mucus. This increases the resistance of the epithelial cells to infection and inflammation.
In contrast to other estrogens estriol has a short-term effect, since it is delayed for a short time in the nuclei of endometrial cells, and subject to the recommended dosing regimen is not to be expected proliferation of the endometrium. In this regard, the cyclical use of progestogens is not necessarily postmenopausal withdrawal bleeding does not occur.

Following oral administration estriol is rapidly and almost completely absorbed in the gastrointestinal tract. The maximum concentration of unconjugated estriol in the plasma is attained within 1 hour after admission. Estriol 90% bound to plasma albumin and unlike other estrogens estriol hardly binds binding globulin sex hormones (SHBG). Metabolism estriol consists mainly of conjugation and deconjugation in the enterohepatic circulation. Estriol, the end product of metabolism appears mainly in urine in conjugated form. Only a small fraction (± 2%) is excreted in the faeces, mainly as unconjugated estriol.

Indications for the application of
atrophy of mucous lower genital tract caused by estrogen deficiency, in particular for the treatment of symptoms such as dyspareunia, vaginal dryness and itching, to prevent recurrent vaginal infections and the lower genital tract; for the treatment of mochevyvedeniya (eg, increased, dysuria) and moderate incontinence;

Pre- and post-operative treatment for operations to the vagina in postmenopausal women;

  • Climacteric disorders, anadrol 50mg such as “hot flashes” and night sweats;
  • As an aid in the preparation of diagnostic picture atrophic cervical smear;
  • Infertility due to cervical factor.Contraindications
  • Pregnancy, lactation;
  • Hypersensitivity to the active and (or) the excipients of the formulation;
  • Known or suspected estrogen-dependent tumors (breast cancer, endometrial cancer);
  • Vaginal bleeding of unknown etiology;
  • The confirmed venous thromboembolism (deep vein thrombosis, pulmonary embolism) within the last two years;
  • Venous thromboembolism, or a history of thrombosis if anticoagulation therapy is not carried out;
  • Diabetes with angiopathy;
  • Sickle-cell anemia;
  • Dubin-Johnson syndrome;
  • Violations of cerebral circulation;
  • Rotor syndrome.Carefully
  • Family hyperlipoproteinemia,
  • An increased risk of thromboembolic complications;
  • Systemic lupus erythematosus;
  • Prolonged immobilisation, major surgery;
  • Severe liver disease;
  • Gallbladder disease in history (especially cholelithiasis);
  • Hepatic porphyria;
  • Severe itching or cholestatic jaundice (including a history during a previous pregnancy..);
  • pancreatitis;
  • Endometriosis;
  • leiomyoma;
  • Bronchial asthma;
  • Arterial hypertension;
  • Hypercalcemia caused by bone metastases of breast cancer;
  • Herpes pregnant;
  • Epilepsy;
  • Otosclerosis.Dosing and Administration
    The drug is used inside. The daily dose in oral administration should not exceed 8 mg. In atrophy of the lower genital tract caused by estrogen deficiency: 4-8 mg per day for the first 4 weeks, followed by tapering in accordance with the symptoms until the maintenance dose of 2.1 mg per day.
    Pre- and post-operative treatment for operations in the vagina in postmenopausal women:. 4-8 mg daily for 2 weeks prior to surgery, 1-2 mg daily for 2 weeks after surgery
    Treatment of menopausal symptoms ( ‘hot flashes’, night sweats): 4-8 mg for a week with a gradual reduction in dose. For maintenance therapy the lowest effective dose should be used.
    If sterility, caused cervical factor: as a rule, appoint 1-2 mg per day 6 to day 15 of the menstrual cycle. However, different patients the daily dose may vary from 1 to 8 mg. The anadrol 50mg dose should be increased every month until the optimum effect on the mucous membrane of the cervix. If you missed taking the next dose, and the delay was not longer than 12 hours, you must take it as soon as possible. If the delay was longer than 12 hours, skip one step further and take the drug at the usual time.
    The tablets are, drinking water, preferably at the same time. The daily dose should be taken at once.

    Side effects:
    Soreness and tension of the mammary glands, jaundice, nausea, skin rash, increased blood pressure, headache, intermenstrual spotting spotting from the vagina, cervical hypersecretion. Adverse reactions are usually transient in nature, but may also indicate a drug overdose.

    Overdose
    If overdose, nausea, vomiting, and vaginal bleeding.
    Treatment is symptomatic.

    Interaction with other medicinal products
    There were no cases of drug interactions Ovestin with other drugs. However, data are available on the strengthening of the pharmacological effect of glucocorticosteroids, lipid-lowering agents or combined with estrogen. If required glucocorticosteroid dose can be reduced.
    It is possible weakening effects of preparations of male sex hormones, anticoagulants, antidepressants, diuretics, hypotensive and hypoglycemic drugs.
    Barbiturates, antiepileptic drugs (carbamazepine, phenytoin) increase the metabolism of steroid hormones.
    Antibiotics (ampicillin, rifampicin) medicines for general anesthesia, narcotic analgesics, anxiolytics, anti-epileptic drugs, some antihypertensive drugs, ethanol reduce estrogen efficiency.
    Folic acid and thyroid hormone drugs enhance the action of estriol.
    estriol can alter the effectiveness of oral anticoagulants, increasing the pharmacological effect suktsinliholina, theophylline, foleandomitsina.

    Special instructions
    Before starting hormone replacement therapy requires a complete medical examination. During treatment every 6 months should be conducted regular surveys (including breast examination, mammography) in accordance with accepted medical practice. It is necessary to exclude the presence of thromboembolism history of repeated spontaneous abortions, indicating thrombophilia. The risk of thromboembolic events increases with prolonged immobilization, severe trauma and surgical interventions. In these cases, the need to temporarily interrupt the hormone replacement therapy (4-6 weeks prior to surgery)
    Use of estriol does not increase the density of the breast. And perhaps the use of estriol does not increase the risk of developing breast cancer.
    Cases of venous thromboembolism (deep vein thrombosis of the lower leg, pelvic venous thrombosis and pulmonary embolism) are seen more often in women receiving hormone replacement therapy. A preparation Ovestin such data are not available, so it anadrol 50mg is not known whether it causes an increase in the use of the frequency of venous thromboembolism. Nevertheless it is recommended to follow the instructions in section “Contraindications”.

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