The frequency of adverse reactions listed below was determined according to the following criteria: very common anavar vs dbol, including isolated reports. From the hematopoietic system: very often – anemia, leukopenia, neutropenia, thrombocytopenia, lymphopenia; often – febrile neutropenia (including grade 3-4), against the backdrop of neutropenia sepsis; rarely – hemolytic anemia, immune thrombocytopenia.
On the part of the digestive system: very often – nausea, vomiting, diarrhea, stomatitis / mucositis, abdominal pain, constipation, loss of appetite; often – indigestion, gastro-oesophageal reflux disease, gastrointestinal bleeding, hiccups, metabolic acidosis, pancreatitis; infrequently – paralytic ileus, intestinal obstruction; rarely – colitis, including pseudomembranous colitis cases. From the hepatobiliary system: very rarely sinusoidal obstruction of the portal blood flow, hepatic peliosis, nodular regenerative hyperplasia of the liver tissue, perisinusoidal fibrosis; clinically manifest complications of portal hypertension and / or increased activity of “liver” transaminases. From the nervous system: very often – Peripheral sensory neuropathy, sensory disturbances, headache, asthenia; often – dizziness, meningismus, depression, insomnia, rarely – increased nervousness; rarely – dysarthria, convulsions.
The neurotoxicity is dose-limiting factor. Sensory neuropathy symptoms are often triggered by the cold. The duration of these symptoms, which are typically dealt with in between courses is increased depending on the total dose of oxaliplatin. Functional disorders in the form of difficulty making precise movements are possible consequences of damage to the sensor.
After the anavar vs dbol cessation of treatment in most cases the severity of neurological symptoms is reduced or they are fully cropped. In 3% of patients at 3 years after the end of treatment were observed or persistent local paresthesias of moderate intensity (2.3%), and paresthesia affecting the functional activity (0.5%). The treatment with oxaliplatin marked acute neurosensory symptoms, which usually occurs within a few hours after administration of the drug and often provoked by exposure to cold. They are characterized by transient paresthesia, dysesthesia or hypoesthesia, rare (1-2%) – an acute syndrome of laryngopharyngeal dysesthesia. Last manifested a subjective sense of dysphagia and dyspnea without objective evidence of respiratory distress syndrome (cyanosis or hypoxia), or spasm of the larynx, or bronchospasm (no stridor or wheezing). Also observed phenomena such as spasm of the jaw muscles, dysesthesia language, dysarthria and a feeling of pressure in the chest. Generally, these symptoms were stopped quickly without using a medical therapy, and when administration of antihistamine and bronchodilators. Increasing the infusion duration with subsequent cycles of therapy with oxaliplatin to reduce the incidence of this syndrome.
From the musculoskeletal system: very often – back pain;often – arthralgia, bone pain. On the part of the respiratory system: very often – cough, shortness of breath; often – rhinitis, upper respiratory tract infection, pain in the chest; rarely – and nterstitsialnaya pneumonia, pulmonary fibrosis. Since the cardiovascular system: often – pain behind the breastbone, deep vein thrombophlebitis, pulmonary embolism. From the mochevydelitelnoy system: often – hematuria, dysuria, hemolytic uremic syndrome, acute tubular necrosis, acute interstitial nephritis, acute renal failure. From the side of the skin and skin appendages: very often – alopecia, skin rash; often – skin peeling palms and soles, erythematous rash, excessive sweating, changes in the nails. From the side of sight and hearing: often – conjunctivitis, blurred vision; . rare – transient blurred vision, loss of visual field, optic neuritis, hearing loss, cochlear neuritis Allergic reactions: rarely (when used as monotherapy) or often (in combination with fluorouracil and folinic acid calcium) can be observed bronchospasm, angioedema , lowering blood pressure, anaphylactic shock. Often there have been cases of allergic reactions anavar vs dbol such as rash (particularly urticaria), conjunctivitis, or rhinitis.
Local reactions: at the extravasation of the drug – redness, pain and inflammatory reactions at the injection site. From the laboratory parameters: often – hypokalemia, hyponatremia, hyperglycemia, increased alkaline phosphatase activity of “liver” enzymes, bilirubin, lakgatdegidrogenazy; often – increased creatinine. Other: very often – fever, increased fatigue, increased body weight, taste disturbance, nasal bleeding.
Overdose Symptoms: myelosuppression, neurotoxicity, diarrhea, nausea, vomiting. The antidote to oxaliplatin is not known. Treatment: hematology control and symptomatic therapy.